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| Title: | Anti-elastase, anti-tyrosinase and antioxidant properties of a peptide fraction obtained from sorghum (Sorghum bicolor L. Moench) grain |
| Authors: | MontalvoGonzález, E.
Alcántara-Quintana, L. E.
Ortiz-Basurto, R. I.
Castro-Jácome, T. P.
Lugo-Cervantes, E.
Tovar-Pérez, E. G. |
| Issue Date: | 2019 |
| Citation: | International Food Research Journal (Malaysia), 26 (6), p. 1813-1822 |
| Abstract: | Nowadays, the food industry are developing products that provide benefits to the skin health, thus representing a new potential market for the application of biopeptides. The aim of the present work was to investigate the elastase and tyrosinase inhibitory and antioxidant activities of the sorghum kafirins-derived peptide fraction (KAF-P) on human skin cultures exposed to ultraviolet B (UVB) irradiation in vitro. Sorghum kafirins were first hydrolysed with alcalase (degree of hydrolysis = 18%). For KAF-P separation, hydrolysates were fractionated by ultrafiltration with a molecular weight cut-off of 3 kDa. It was observed that exposure to UVB induced overactivity of elastase and tyrosinase, as well as decrease in the activity of the antioxidant enzyme system [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)]. Treatment with KAF-P inhibited elastase and tyrosinase. Moreover, KAF-P attenuated the reduction in the activities of SOD, CAT, and GPx; and maintained or enhanced the activity of these enzymes in normal human skin in vitro. These anti-elastase, anti-tyrosinase, and antioxidant properties of KAF-P were similar to those obtained with glutathione, which is a peptide that plays an important role in protecting skin cells against UVB. The results suggest that KAF-P is able to intervene in the biochemical reactions of the skin and could, therefore, be considered as a potential candidate for the design of new nutricosmetics and skin-care products. |
| License: | http://www.oceandocs.org/license |
| URI: | http://agris.upm.edu.my:8080/dspace/handle/0/18913 |
| Related document: | http://www.ifrj.upm.edu.my/26%20(06)%202019/18%20-... |
| ISSN: | 0116-6514 |
| Appears in Collections: | Publications
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